We celebrated the x-mas with a potluck lunch where we organized an image contest for our 2024 calendar. With the tasty food, it was great to vote for the best images captured by the group members. Special thanks to Doke for organizing this event!
With this funded grant, we will develop better hydrogel-integrated microfluidic platforms to examine cell-material interactions. Our focus will be the interplay between the stiffness and hydrogel adaptability for the control of cell behavior.
In a team of researchers from Sabanci University Nanotechnology Research and Application Center (SUNUM), TUBITAK Marmara Research Center (TUBITAK-MAM), Koç University Research Center for Translational Medicine (KUTTAM) and Izmir Biomedicine and Genome Center (IBG), we got a funding of 3,7 million Eur from Horizon Europe CoFund program. The topic is about developing "Nanobiotechnologies for Innovative Therapeutic Approaches for Cancer". The programfocuses on cancer research while providing a tailor-made accelerator programme to educate tomorrow’s researchers in a broad set of scientific, transferable, and business skills to develop the mindset of an entrepreneur in parallel to the academic career.
We are looking forward to collaborating with excellent researchers in the next 5 years!
Oksana is an invited member of the organization committee of SAFE/ProRISC conference 2024.
In 2023, the conference took place - and Oksana presented a poster
Congrats to our MicroTAS 2023 poster presenters Lanhui, Mert and Oksana.
Carina is on ICMS news!
Ana Carina Manjua fell in love with biomedical research during her master's at the New University of Lisbon, when studying electroconductive materials as biobatteries for pacemakers. During her PhD at the Instituto Superior Técnico in the same city, she worked on building a microchip to regenerate blood vessels. After that, she worked 1.5 years in a biomaterials company. Manjua returned to research last March as a EuroTech postdoc at the TU/e Biosensors and Devices Lab. She will again work on microchips, this time in the context of cardiovascular diseases. The goal is to remodel cardiac tissue on a chip and recreate its micro-environment in order to simulate the disease and find ways to regenerate the tissue. Manjua’s research will include the microchip design, developing a hydrogel for electromagnetic stimulation to regenerate cells, building a stretchable platform – at the Swiss University EPFL – to simulate cardiac rhythm, and arranging a computational interface, before she can actually study the cardiac tissue.
Burcu delivers an invited talk at GRC Physics and Chemistry of Microfluidics Edition 2023.
This talk covered how we handle the digital microfluidics systems in the scope of regenerative medicine and our attempt to improve the system to create unique cellular microenvironments. We are honored to be a part of this community! Looking forward to joining the next editions.
We join the annual symposium by Institute for Complex Molecular Systems at TU/e.
BDL is a Institute for Complex Molecular Systems (ICMS) affiliate & enjoy making science together. This year the annual event is hosted by all TU/e-based exciting speakers on 30-31 March 2023. Burcu co-chairs the first day of the event. Feel free to join us!
Paper alert! Our collaboration with Radboud UMC resulted in a Biosensors paper, just published. Congrats to all authors.
In the paper entitled "Co-culture of glomerular endothelial cells and podocytes in a custom-designed glomerulus-on-a-chip model improves the filtration barrier integrity and affects the glomerular cell phenotype", we build a functional microfluidic environment supported with perforated polycarbonate membrane to rebuild glomerulus units in the kidney. Lanhui and Burcu contributed to this work in the design and fabrication phases.
Carina Manjua joins our group as a postdoctoral fellow. Welcome, Carina!
2023 winter season group outing at BDL and BiS.
Members of Biosensors and Devices Lab and Biointerface Science went on the ice. Some of us skated hard, others sent their good wishes from the sideline. Either way was fun!
Our lab's first bachelor end project students Tess, Valerie, and Christian graduated successfully! They collaboratively worked on materials to mimic ECM and how the stiffness of the environment relates to cell behavior from different perspectives including diffusion time, cell morphology, and stiffness changes. Their studies were guided by Oksana and Esmee. Well done!
Emy worked on light-responsive dynamic surfaces embedded in microfluidics platform to study immune cell-material interactions during her studies. She found that macrophages respond to height and stiffness changes at various levels.
Ruth Verbroekken joins BDL as a joint Ph.D. student! Welcome, Ruth!
Ruth will work on developing light-responsive surface patterns, which will be integrated into a microfluidic platform to explore the cell-material response of macrophages. Ruth is a joint Ph.D. student of the Chemical Engineering and Biomedical Engineering Departments.
Mert Ozden joins our lab as a Ph.D. candidate. He will be working on innovating the digital microfluidic platform for high content screening. Heartily welcome, Mert!
Congratulations Lanhui on being selected to deliver an oral presentation at NBTE conference 2022.
BDL exhibits at Dutch Design Week 2022 in collaboration with designer Piet Hein Eek.
This year we collaborate with Dutch designer Piet Hein Eek to demonstrate atherosclerosis-on-chip. Dutch Design week is held between 22-30 October 2022.
How does “design” change its meaning in functional (or a word that Piet prefers) and scientific perspectives?
Through our journey to bring different designers collaborating, we noticed that the word “design” can bear different meanings. Therefore, we share what we found out: Piet (PHE) and Burcu (Eindhoven University of Technology, Biomedical Engineering Department) joined forces to approach functional design from different perspectives. While Piet is good at designing macro-scale objects that find use in households, Burcu designs micro-scale objects for research purposes.
For Piet, design is a word to create a functional product that he can foresee its use, while for Burcu design is a word to create a functional platform to explore the unforeseen, mostly for the understanding of medical problems.
Hereby, Piet and Burcu present a micron-scale construct made using the logo of Piet Hein Eek (PHE). This design mimics the branching veins in the body to study atherosclerosis, a health-related disorder resulting in clogged veins, which require the placement of stents. The logo of PHE appeared as an easy-to-fabricate and -operate design, therefore it was interesting to choose it to model the blood flow velocity in veins.
Through simulations, we found that the branching sides having a slower flow rate when compared to the main channels. Through experiments, real cells reacted to the flow by accumulating in low-flow-rate regions and migrating in high-flow rate regions. Our observation is in accordance with medical findings that regions with more cell accumulation were predicted to be more prone to atherosclerosis. Therefore, we can use this model to study the biology of this disease further and propose new treatment strategies!
Heartily welcome to Guillem Monso who will develop AI-Brain on chip platform in his Ph.D. work!
Esmee Meijerhof successfully defends her M.Sc. thesis.
Esmee worked on the development of a pulse-on-chip microfluidic platform with magnetic hydrogel valve to study mechanobiology during her M.Sc. studies. Today She successfully defended her work. We were really happy to have her around! Good luck with your future work Esmee, but before it is the well-deserved holiday time!
We kicked off the Lab on a Chip Microdevices course.
This year, we run a pilot of the Lab on a Chip Microdevices course. Today we finished the first lab session, and it was so much fun to make chips together. Our student team is dealing with a real problem assigned by Emultech, a high-tech campus company. The project is about generating stable water-in-water droplets. This challenge could not be easier without the help of Lanhui and Kalpit. Exciting!
Esmée van der Vliet joins our team as a M.Sc. student. Welcome, Esmée!
She will be working on building a glial scar on chip using hydrogels with different stiffness properties.
Paper out! We publish a review paper on engineering organ-on-a-chip to accelerate translational research.
With our collaborator Prof. Noo Li Jeon at Seoul National University, we prepared an educational review paper on engineering organ-on-a-chip to accelerate translational research. We provide an overview of what is organ-on-chip, where it can be used, what it is composed of, how it can be fabricated, and how it can be operated. We also revisited the recent applications, where different organs are modeled on the microscale using this technology.
Carina will join our lab in February 2023 to work on high-throughput stimuli-responsive screening microchips for cardiac tissue remodeling in collaboration with our partners at EPFL and TU/e Biomedical Engineering.
Burcu joins the review editorial board of Frontiers in Lab on a Chip Technologies Journal.
Burcu gives a Keynote talk at the Netherlands Society for Biomaterials and Tissue Engineering (NBTE) 30th Annual Meeting.
NBTE is a society that aims to promote the interests of biomaterials science and tissue engineering in the Netherlands and to stimulate cooperation between universities, institutions and industries in these domains. In 2022, NBTE is celebrating the 30st anniversary!
Burcu's Keynote is about Lab on a Chip Devices for Bioclinical Applications. Follow the link below for more information.