Regenerative medicine challenges are difficult to study due to the complexity of the biological systems. Conventional cell culturing has been the workhorse for regenerative medicine studies; however, these information-rich method cannot always maintain the desired degree of precision. We design and develop digital microfluidic systems to achieve precisely controllable conditions for cell culturing. In digital microfluidic systems, we make use of electrowetting phenomena to guide droplets on a surface without physically touching them.